Article

The microbiome shapes immunity in a sex-specific manner in mouse models of Alzheimer’s disease

2024-05-08

Abstract excerpt

INTRODUCTION : Preclinical studies reveal that the microbiome broadly affects immune responses and deposition and/or clearance of amyloid-beta (Aβ) in mouse models of Alzheimer’s disease (AD). Whether the microbiome shapes central and peripheral immune profiles in AD models remains unknown. METHODS : We examined adaptive immune responses in two mouse models containing AD- related genetic predispositions (3xTg and...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 74821d25-e590-55e8-8a75-af77c52006e3
DOI: 10.1101/2024.05.07.593011

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The microbiome shapes immunity in a sex-specific manner in mouse models of Alzheimer’s diseaseDOI 10.1101/2024.05.07.593011Read

Genotype and microbiome shape immunity in a sex-specific manner in mouse models of Alzheimer’s diseaseSemantic proximity Read

Ad-derived bone marrow transplant induces proinflammatory immune peripheral mechanisms accompanied by decreased neuroplasticity and reduced gut microbiome diversity affecting AD-like phenotype in the absence of Aβ neuropathology.Semantic proximity Read

Gut Microbiome rewiring via fecal transplants: Uncovering therapeutic avenues in Alzheimer’s disease modelsSemantic proximity Read

Alterations in the Gut-Microbial-Inflammasome-Brain Axis in a Mouse Model of Alzheimer’s DiseaseSemantic proximity Read

Microbiome Alterations and Alzheimer’s Disease: Modeling Strategies with Transgenic MiceSemantic proximity Read

Predicting neurodegenerative disease using pre-pathology gut microbiota composition: a longitudinal study in mice modeling Alzheimer’s disease pathologiesSemantic proximity Read

Sex-Specific Gut Microbiome Functions in Alzheimer’s Disease BXD MiceSemantic proximity Read

The impact of APOE genotype, age, and sex on gut microbiota in a mouse model of Alzheimer's Disease: an exploration of their interactions.Semantic proximity Read

Longitudinal Analysis of the Microbiome and Metabolome in the 5xfAD Mouse Model of Alzheimer’s DiseaseSemantic proximity Read

Impact of Acute and Chronic Amyloid-β Peptide Exposure on Gut Microbial Commensals in the MouseSemantic proximity Read

Transmission of Alzheimer’s disease-associated microbiota dysbiosis and its impact on cognitive function: evidence from mice and patientsSemantic proximity Read

Sex-specific effects of microbiome perturbations on cerebral Aβ amyloidosis and microglia phenotypesSemantic proximity Read