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The impact of APOE genotype, age, and sex on gut microbiota in a mouse model of Alzheimer's Disease: an exploration of their interactions.

Biology of sex differences - 19 Apr 2026

Mi Xue, Zhang Yi-Chi, Zhang Xu-Jun, He Hao-Bing, Chen Xiao-Chun, Dai Xiao-Man

Abstract excerpt

BACKGROUND: As an important interface between the peripheral environment and the central nervous system, the gut microbiota varies greatly between patients or animals with Alzheimer's disease (AD) and their respective non-AD counterparts; however, it remains unexplored whether the apolipoprotein E (APOE) genotype, age, and sex may interactively influence the characteristics of gut microbiota in AD animals....

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Source

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Identifiers

PMID: 42002820
DOI: 10.1186/s13293-026-00905-w
PMCID: PMC13224529

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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