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Article

Sex-specific effects of microbiome perturbations on cerebral Aβ amyloidosis and microglia phenotypes

16 May 2019

Abstract excerpt

We demonstrated that an antibiotic cocktail (ABX)-perturbed gut microbiome is associated with reduced amyloid-β (Aβ) plaque pathology and astrogliosis in the male amyloid precursor protein (APP)SWE/presenilin 1 (PS1)ΔE9 transgenic model of Aβ amyloidosis. We now show that in an independent, aggressive APPSWE/PS1L166P (APPPS1-21) mouse model of Aβ amyloidosis, an ABX-perturbed gut microbiome is associated with a...

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PMID: 31097468
DOI: 10.1084/jem.20182386

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