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Genotype and microbiome shape immunity in a sex-specific manner in mouse models of Alzheimer’s disease

28 Jul 2025

Abstract excerpt

Preclinical studies have revealed that the microbiome broadly affects immune responses and deposition and/or clearance of amyloid-beta (Aβ) in mouse models of Alzheimer's disease (AD), but whether, and how, the microbiome shapes central and peripheral immune profiles in AD models remains unknown. We examined adaptive immune responses in two mouse models containing AD-related genetic predispositions (3xTg and...

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PMID: 40738263
DOI: 10.1016/j.bbi.2025.07.028

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