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Impact of Acute and Chronic Amyloid-β Peptide Exposure on Gut Microbial Commensals in the Mouse

20 May 2020

Abstract excerpt

Alzheimer’s disease (AD) is the most common form of dementia. Besides its cognitive phenotype, AD leads to crucial changes in gut microbiome composition in model mice and in patients, but the reported data are still highly inconsistent. Therefore, we investigated chronic effects of AD-characteristic neurotoxic amyloid-β peptides (Aβ) as provided by transgenic overexpression (5xFAD mouse model) and acute effects...

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PMID: 32508799
DOI: 10.3389/fmicb.2020.01008

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