Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Selective activation of vitamin D receptor by lithocholic acid acetate, a bile acid derivative.

Journal of lipid research - 1 Jan 2005

Adachi Ryutaro, Honma Yoshio, Masuno Hiroyuki, Kawana Katsuyoshi, Shimomura Iichiro, Yamada Sachiko, Makishima Makoto

Abstract excerpt

The vitamin D receptor (VDR), a member of the nuclear receptor superfamily, mediates the biological actions of the active form of vitamin D, 1alpha,25-dihydroxyvitamin D(3). It regulates calcium homeostasis, immunity, cellular differentiation, and other physiological processes. Recently, VDR was found to respond to bile acids as well as other nuclear receptors, farnesoid X receptor (FXR) and pregnane X receptor...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bile Acids and Salts
Share to Cell Differentiation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Line, Tumor

Share to Cell Proliferation

Share to Leukemia, Monocytic, Acute

Share to Mice, Inbred C57BL

Share to Receptors, Calcitriol

Share to Structure-Activity Relationship

Source

Identifiers

PMID: 15489543
DOI: 10.1194/jlr.M400294-JLR200

Genes

VDR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Selective activation of vitamin D receptor by lithocholic acid acetate, a bile acid derivative.PMID 15489543Read ↗

Structural insights into the molecular mechanism of vitamin D receptor activation by lithocholic acid involving a new mode of ligand recognition.Semantic proximity Read ↗

A microbial metabolite, Lithocholic acid, suppresses IFN-γ and AhR expression by human cord blood CD4 T cellsSemantic proximity Read ↗

International Union of Pharmacology. LX. Retinoic acid receptors.Semantic proximity Read ↗

Structural Basis of Novel Bile Acid-Based Modulators of FXRSemantic proximity Read ↗

Revealing a natural marine product as a novel agonist for retinoic acid receptors with a unique binding mode and inhibitory effects on cancer cellsSemantic proximity Read ↗

The bacterial metabolite, lithocholic acid, has antineoplastic effects in pancreatic adenocarcinomaSemantic proximity Read ↗

The development and characterization of bile acid-derived agonists of FXR towards NASH treatmentSemantic proximity Read ↗

International Union of Pharmacology. LXII. The NR1H and NR1I receptors: constitutive androstane receptor, pregnene X receptor, farnesoid X receptor alpha, farnesoid X receptor beta, liver X receptor alpha, liver X receptor beta, and vitamin D receptor.Semantic proximity Read ↗

Evolution and function of the NR1I nuclear hormone receptor subfamily (VDR, PXR, and CAR) with respect to metabolism of xenobiotics and endogenous compounds.Semantic proximity Read ↗

International Union of Pharmacology. LXIII. Retinoid X receptors.Semantic proximity Read ↗

Chemical genomics: Functional analysis of orphan nuclear receptors in the regulation of bile acid metabolismSemantic proximity Read ↗

Structure and Function of the Human Nuclear Xenobiotic Receptor PXRSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.