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Article

High-fat diet reprograms the epigenome of rat spermatozoa and transgenerationally affects metabolism of the offspring

25 Dec 2015

Abstract excerpt

OBJECTIVES: Chronic and high consumption of fat constitutes an environmental stress that leads to metabolic diseases. We hypothesized that high-fat diet (HFD) transgenerationally remodels the epigenome of spermatozoa and metabolism of the offspring. METHODS: F0-male rats fed either HFD or chow diet for 12 weeks were mated with chow-fed dams to generate F1 and F2 offspring. Motile spermatozoa were isolated from F0...

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PMID: 26977389
DOI: 10.1016/j.molmet.2015.12.002

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