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Article

Emerging β-Sheet Rich Conformations in Supercompact Huntingtin Exon-1 Mutant Structures.

Journal of the American Chemical Society - 5 Jul 2017

Kang Hongsuk, Vázquez Francisco X, Zhang Leili, Das Payel, Toledo-Sherman Leticia, Luan Binquan, Levitt Michael, Zhou Ruhong

Abstract excerpt

There exists strong correlation between the extended polyglutamines (polyQ) within exon-1 of Huntingtin protein (Htt) and age onset of Huntington's disease (HD); however, the underlying molecular mechanism is still poorly understood. Here we apply extensive molecular dynamics simulations to study the folding of Htt-exon-1 across five different polyQ-lengths. We find an increase in secondary structure motifs at...

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Identifiers

PMID: 28609090
DOI: 10.1021/jacs.7b00838
PMCID: PMC5835228

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