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Genome-wide association studies for Alzheimer’s disease: bigger is not always better

2 May 2022

Abstract excerpt

As the size of genome-wide association studies increase, the number of associated trait loci identified inevitably increase. One welcomes this if it allows the better delineation of the pathways to disease and increases the accuracy of genetic prediction of disease risk through polygenic risk score analysis. However, there are several problems in the continuing increase in the genome-wide analysis of 'Alzheimer's...

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PMID: 35663382
DOI: 10.1093/braincomms/fcac125

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