Article

Molecular mechanism of substrate recognition by folate transporter SLC19A1

2022-09-10

Abstract excerpt

Folate (vitamin B 9 ) is the coenzyme involved in one-carbon transfer biochemical reactions essential for cell survival and proliferation, with its inadequacy causing developmental defects or severe diseases. Notably, mammalian cells lack the ability to de novo synthesize folate but instead rely on its intake from extracellular sources via specific transporters or receptors, among which SLC19A1 is the ubiquitous...

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Literature Corpus work: 1bc14c26-ceb3-504e-9aef-54e3ab99512e
DOI: 10.1101/2022.09.09.507238

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