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Article

Modeling Motor Neuron Resilience in ALS Using Stem Cells

9 May 2019

Abstract excerpt

Oculomotor neurons, which regulate eye movement, are resilient to degeneration in the lethal motor neuron disease amyotrophic lateral sclerosis (ALS). It would be highly advantageous if motor neuron resilience could be modeled in vitro. Toward this goal, we generated a high proportion of oculomotor neurons from mouse embryonic stem cells through temporal overexpression of PHOX2A in neuronal progenitors. We...

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PMID: 31080111
DOI: 10.1016/j.stemcr.2019.04.009

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