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Modeling ALS and FTD with iPSC-derived neurons

22 Oct 2015

Abstract excerpt

Recent advances in genetics and neuropathology support the idea that amyotrophic lateral sclerosis (ALS) and frontotemporal lobar dementia (FTD) are two ends of a disease spectrum. Although several animal models have been developed to investigate the pathogenesis and disease progression in ALS and FTD, there are significant limitations that hamper our ability to connect these models with the neurodegenerative...

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PMID: 26462653
DOI: 10.1016/j.brainres.2015.10.003

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