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A thymus-independent artificial organoid system supports complete thymopoiesis from Rhesus macaque-derived hematopoietic stem and progenitor cells

2025-09-04

Abstract excerpt

Thymic output has been extensively studied. While advanced ex-vivo T cell generative approaches exist for mouse and human models, such advancements for nonhuman primate model are lacking. We report the establishment of a rhesus macaque-specific artificial thymic organoid (Rh-ATO) system enabling robust ex vivo T cell generation from CD34⁺ hematopoietic stem and progenitor cells (HSPCs). A continuum of distinct thy...

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Literature Corpus work
883c7d2c-4fe1-5660-9203-d45bae66d80c
DOI
10.1101/2025.08.29.673172
Open publication

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A thymus-independent artificial organoid system supports complete thymopoiesis from Rhesus macaque-derived hematopoietic stem and progenitor cellsDOI 10.1101/2025.08.29.673172
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