Article

SF3B1 phosphorylation is an evolutionarily conserved step in spliceosome activation carried out by the divergent, OTS964-insensitive kinase CRK9 in trypanosomes

2025-11-21

Abstract excerpt

SF3B1 is a subunit of the heptameric SF3B complex which, as part of the U2 small nuclear ribonucleoprotein, facilitates branch point recognition in pre-mRNA splicing. In addition to this early-stage function, it was recently shown that activation of the spliceosome depends on the phosphorylation of threonine-proline (TP) motifs in SF3B1’s N-terminal domain (NTD) by cyclin-dependent kinase 11 (CDK11). This breakthr...

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Literature Corpus work: 74101131-95a3-569b-9432-8d1e885a5bed
DOI: 10.1101/2025.11.20.689580

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