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The Pre-mRNA Splicing Machinery of Trypanosomes: Complex or Simplified?

26 Jun 2010

Abstract excerpt

Trypanosomatids are early-diverged, protistan parasites of which Trypanosoma brucei, Trypanosoma cruzi, and several species of Leishmania cause severe, often lethal diseases in humans. To better combat these parasites, their molecular biology has been a research focus for more than 3 decades, and the discovery of spliced leader (SL) trans splicing in T. brucei established a key difference between parasites and...

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PMID: 20581293
DOI: 10.1128/ec.00113-10

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The Pre-mRNA Splicing Machinery of Trypanosomes: Complex or Simplified?PMID 20581293Read ↗

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Beyond the transcript: chromatin implications in trans-splicing in TrypanosomatidsSemantic proximity Read ↗

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Comprehensive analysis of the Kinetoplastea intron landscape reveals a novel intron-containing gene and the first exclusively trans-splicing eukaryoteSemantic proximity Read ↗

Trypanosomal TBP Functions with the Multisubunit Transcription Factor tSNAP To Direct Spliced-Leader RNA Gene ExpressionSemantic proximity Read ↗

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