Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Distinct mRNA and protein interactomes highlight functional differentiation of major eIF4F-like complexes from Trypanosoma brucei

7 Oct 2022

Abstract excerpt

Gene expression in pathogenic protozoans of the family Trypanosomatidae has several novel features, including multiple eIF4F-like complexes involved in protein synthesis. The eukaryotic eIF4F complex, formed mainly by eIF4E and eIF4G subunits, is responsible for the canonical selection of mRNAs required for the initiation of mRNA translation. The best-known complexes implicated in translation in trypanosomatids...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biochemical and Molecular Research
Share to Research on Leishmaniasis Studies
Share to Trypanosoma species research and implications

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36275617
DOI: 10.3389/fmolb.2022.971811

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Distinct mRNA and protein interactomes highlight functional differentiation of major eIF4F-like complexes from Trypanosoma bruceiPMID 36275617Read ↗

Comparative proteomics of the two T. brucei PABPs suggests that PABP2 controls bulk mRNASemantic proximity Read ↗

The two eIF4A helicases in Trypanosoma brucei are functionally distinct.Semantic proximity Read ↗

Architecture, domain organization and functional signatures of trypanosomatid keIF4A1s and Plasmodium peIF4A1s suggest conserved functionsSemantic proximity Read ↗

LeishIF4E-5 Is a Promastigote-Specific Cap-Binding Protein in LeishmaniaSemantic proximity Read ↗

The translation initiation complex eIF3 in trypanosomatids and other pathogenic excavates--identification of conserved and divergent features based on orthologue analysis.Semantic proximity Read ↗

Gene expression regulatory networks in <scp><i>T</i></scp><i>rypanosoma brucei</i>: insights into the role of the mRNA‐binding proteomeSemantic proximity Read ↗

Evolutionary Conservation and Diversification of the Translation Initiation Apparatus in TrypanosomatidsSemantic proximity Read ↗

Human tissues exhibit diverse composition of translation machinerySemantic proximity Read ↗

Structural differences in translation initiation between pathogenic trypanosomatids and their mammalian hostsSemantic proximity Read ↗

Extensive Translational Regulation through the Proliferative Transition of Trypanosoma cruzi Revealed by Multi-OmicsSemantic proximity Read ↗

mRNA cap-binding protein eIF4E1 is a novel regulator of <i>Toxoplasma gondii</i> latencySemantic proximity Read ↗

Functionally related transcripts have common RNA motifs for specific RNA-binding proteins in trypanosomes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.