Article

Fast principal components analysis reveals convergent evolution of ADH1B gene in Europe and East Asia

2015-04-16

Abstract excerpt

Searching for genetic variants with unusual differentiation between subpopulations is an established approach for identifying signals of natural selection. However, existing methods generally require discrete subpopulations. We introduce a method that infers selection using principal components (PCs) by identifying variants whose differentiation along top PCs is significantly greater than the null distribution of...

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Literature Corpus work: 73f0c70d-2ad4-5f66-a9ee-1a3128e97406
DOI: 10.1101/018143

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