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Article

Tracing sub-structure in the European American population with PCA-informative markers.

PLoS genetics - 4 Jul 2008

Paschou Peristera, Drineas Petros, Lewis Jamey, Nievergelt Caroline M, Nickerson Deborah A, Smith Joshua D, Ridker Paul M, Chasman Daniel I, Krauss Ronald M, Ziv Elad

Abstract excerpt

Genetic structure in the European American population reflects waves of migration and recent gene flow among different populations. This complex structure can introduce bias in genetic association studies. Using Principal Components Analysis (PCA), we analyze the structure of two independent European American datasets (1,521 individuals-307,315 autosomal SNPs). Individual variation lies across a continuum with...

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Identifiers

PMID: 18797516
DOI: 10.1371/journal.pgen.1000114
PMCID: PMC2537989

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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