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Article

Fast Principal-Component Analysis Reveals Convergent Evolution of ADH1B in Europe and East Asia.

American journal of human genetics - 3 Mar 2016

Galinsky Kevin J, Bhatia Gaurav, Loh Po-Ru, Georgiev Stoyan, Mukherjee Sayan, Patterson Nick J, Price Alkes L

Abstract excerpt

Searching for genetic variants with unusual differentiation between subpopulations is an established approach for identifying signals of natural selection. However, existing methods generally require discrete subpopulations. We introduce a method that infers selection using principal components (PCs) by identifying variants whose differentiation along top PCs is significantly greater than the null distribution of...

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Identifiers

PMID: 26924531
DOI: 10.1016/j.ajhg.2015.12.022
PMCID: PMC4827102

Genes

IGFBP3
IGH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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