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Clinical Utility and Implementation of Pharmacogenomics for the Personalisation of Antipsychotic Treatments

7 Feb 2024

Abstract excerpt

Decades of pharmacogenetic research have revealed genetic biomarkers of clinical response to antipsychotics. Genetic variants in antipsychotic targets, dopamine and serotonin receptors in particular, and in metabolic enzymes have been associated with the efficacy and toxicity of antipsychotic treatments. However, genetic prediction of antipsychotic response based on these biomarkers is far from accurate. Despite...

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PMID: 38399298
DOI: 10.3390/pharmaceutics16020244

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