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Article

Clozapine Pharmacogenetic Studies in Schizophrenia: Efficacy and Agranulocytosis

26 Sept 2018

Abstract excerpt

Clozapine is an efficacious atypical antipsychotic for treatment-refractory schizophrenia. Clinical response and appearance of adverse events vary among individual patients receiving clozapine, with genetic and non-genetic factors potentially contributing to individual variabilities. Pharmacogenetic studies investigate associations between genetic variants and drug efficacy and toxicity. To date, most...

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Identifiers

PMID: 30319405
DOI: 10.3389/fphar.2018.01049

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