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Article

Revealing de novo pyrimidine synthesis as a key vulnerability in brain tumors.

Cancer cell - 12 Dec 2022

Schild Tanya, Keshari Kayvan R

Abstract excerpt

Brain tumors are notoriously difficult to treat. Three recent Cancer Cell articles aim to uncover novel druggable targets in IDH mutant gliomas, diffuse midline gliomas, and medulloblastomas, respectively, and show that these brain tumor types shift their metabolism to become reliant on de novo pyrimidine synthesis.

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Identifiers

PMID: 36400017
DOI: 10.1016/j.ccell.2022.10.023

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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