Adaptation by stochastic tuning of gene expression in mammalian cells

Abstract excerpt

Cells often face environmental challenges for which they lack pre-programmed regulatory responses. We have previously shown that yeast cells can, nevertheless, adapt to such unfamiliar conditions by a phenomenon we have termed stochastic tuning. In this process, cells use gene expression noise to randomly change the expression of individual genes and actively reinforce those changes that improve the overall health...

Topics

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• Adaptation, Physiological
• Algorithms
• Chromatin
• Gene Expression Regulation, Fungal
• Gene Regulatory Networks
• Genome, Fungal
• Stochastic Processes
• Whole Genome Sequencing

Identifiers and source

Literature Corpus work

4e6abe6d-15ad-5a6a-9adf-2a0a6d769514

DOI

10.1101/2025.05.07.651953