Article

Model-guided design of microRNA-based gene circuits supports precise dosage of transgenic cargoes into diverse primary cells

2024-06-25

Abstract excerpt

To realize the potential of engineered cells in therapeutic applications, transgenes must be expressed within the window of therapeutic efficacy. Differences in copy number and other sources of extrinsic noise generate variance in transgene expression and limit the performance of synthetic gene circuits. In a therapeutic context, supraphysiological expression of transgenes can compromise engineered phenotypes and...

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Literature Corpus work: a538d90b-6622-511b-aaa8-71eb0a02324e
DOI: 10.1101/2024.06.25.600629

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