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Genipin Alleviates Sleep Deficiencies Caused by α-Synuclein Toxicity in a <i>Drosophila melanogaster</i> Model of Parkinson’s Disease

2026-07-21

Abstract excerpt

Parkinson’s disease is predominantly characterized by dopaminergic neurodegeneration linked to toxic aggregation of α-synuclein. Genipin, a bioactive iridoid, was previously shown to improve the motility and survival deficits caused by pan-neuronal expression of native α-synuclein in a transgenic Drosophila melanogaster model system. We show that expression of α-synuclein causes sleep deficits and that genipin tr...

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Literature Corpus work
73b465e8-8153-5c89-a19e-fc865755c49a
DOI
10.64898/2026.07.16.738995
Open publication

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Genipin Alleviates Sleep Deficiencies Caused by α-Synuclein Toxicity in a <i>Drosophila melanogaster</i> Model of Parkinson’s DiseaseDOI 10.64898/2026.07.16.738995
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