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Article

Pink1 suppresses alpha-synuclein-induced phenotypes in a Drosophila model of Parkinson's disease.

Genome - 1 Dec 2008

Todd Amy M, Staveley Brian E

Abstract excerpt

Parkinson's disease (PD) is the most prevalent human neurodegenerative movement disorder and is characterized by a selective and progressive loss of the dopaminergic neurons. Mutations in the genes parkin and PTEN-induced putative kinase 1 (PINK1) result in autosomal recessive forms of PD. It has been suggested that parkin and Pink1 function in the same pathway in Drosophila, with Pink1 acting upstream of parkin....

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Identifiers

PMID: 19088817
DOI: 10.1139/G08-085

Genes

PINK1
PTEN

Provenance

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Related research

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Research trail→

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Pink1 suppresses alpha-synuclein-induced phenotypes in a Drosophila model of Parkinson's disease.PMID 19088817Read ↗

parkin counteracts symptoms in a Drosophila model of Parkinson's diseaseSemantic proximity Read ↗

Expression of Pink1 with α-synuclein in the dopaminergic neurons of Drosophila leads to increases in both lifespan and healthspanSemantic proximity Read ↗

Analysis of α-syn and parkin interaction in mediating neuronal death in Drosophila model of Parkinson's diseaseSemantic proximity Read ↗

Mutant α-synuclein-induced degeneration is reduced by <i>parkin </i>in a fly model of Parkinson's diseaseSemantic proximity Read ↗

Mitochondrial dysfunction and Parkinson's disease genes: insights from Drosophila.Semantic proximity Read ↗

Alpha-synuclein-induced neurodegeneration is exacerbated in PINK1 knockout mice.Semantic proximity Read ↗

Pharmacological PINK1 activation ameliorates Pathology in Parkinson’s Disease modelsSemantic proximity Read ↗

Elevated α-synuclein levels inhibit mitophagic fluxSemantic proximity Read ↗

A Drosophila model of mutant human parkin-induced toxicity demonstrates selective loss of dopaminergic neurons and dependence on cellular dopamine.Semantic proximity Read ↗

The PINK1/Parkin pathway regulates mitochondrial morphology.Semantic proximity Read ↗

TRAP1 rescues PINK1 loss-of-function phenotypesSemantic proximity Read ↗

Drosophila overexpressing parkin R275W mutant exhibits dopaminergic neuron degeneration and mitochondrial abnormalities.Semantic proximity Read ↗

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