Article

Haploinsufficiency of Parkinsonism Gene <i>SYNJ1</i> Contributes to Dopamine neuron Vulnerability in Aged Mice

2017-12-13

Abstract excerpt

Parkinson’s disease (PD) is an age-dependent neurodegenerative disorder characterized by the loss of substantia nigra dopaminergic (DAergic) neurons in ventral midbrain (MB). Identification of interactions between aging and the known risk variants is crucial to understanding the etiology of PD. Recessive mutations in SYNJ1 have recently been linked to familial early-onset atypical Parkinsonism. We now show an age...

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Literature Corpus work: 6bec5d76-2630-5a09-bdb8-6b8951b5d07b
DOI: 10.1101/233585

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