Article
Extracellular matrix in lung development, homeostasis and disease.
Matrix biology : journal of the International Society for Matrix Biology - 1 Nov 2018
Zhou Yong, Horowitz Jeffrey C, Naba Alexandra, Ambalavanan Namasivayam, Atabai Kamran, Balestrini Jenna, Bitterman Peter B, Corley Richard A, Ding Bi-Sen, Engler Adam J, Hansen Kirk C, Hagood James S, Kheradmand Farrah, Lin Qing S, Neptune Enid, Niklason Laura, Ortiz Luis A, Parks William C, Tschumperlin Daniel J, White Eric S, Chapman Harold A, Thannickal Victor J
Abstract excerpt
The lung's unique extracellular matrix (ECM), while providing structural support for cells, is critical in the regulation of developmental organogenesis, homeostasis and injury-repair responses. The ECM, via biochemical or biomechanical cues, regulates diverse cell functions, fate and phenotype. The composition and function of lung ECM become markedly deranged in pathological tissue remodeling. ECM-based...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.