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Article

A model for the pharmacological treatment of crouzon syndrome.

Neurosurgery - 1 Jul 2006

Perlyn Chad A, Morriss-Kay Gillian, Darvann Tron, Tenenbaum Marissa, Ornitz David M

Abstract excerpt

OBJECTIVE: Crouzon syndrome is caused by mutations in fibroblast growth factor receptor 2 (FGFR2) leading to constitutive activation of receptors in the absence of ligand binding. The syndrome is characterized by premature fusion of the cranial sutures that leads to abnormal cranium shape, restricted brain growth, and increased intracranial pressure. Surgical remodeling of the cranial vault is currently used to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16823318
DOI: 10.1227/01.NEU.0000224323.53866.1E
PMCID: PMC2267918

Genes

FGFR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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