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MARS an improved de novo peptide candidate selection method for non-canonical antigen target discovery in cancer

22 Jan 2024

Abstract excerpt

Understanding the nature and extent of non-canonical human leukocyte antigen (HLA) presentation in tumour cells is a priority for target antigen discovery for the development of next generation immunotherapies in cancer. We here employ a de novo mass spectrometric sequencing approach with a refined, MHC-centric analysis strategy to detect non-canonical MHC-associated peptides specific to cancer without any prior...

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PMID: 38253617
DOI: 10.1038/s41467-023-44460-z

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