Article

Cardiac Profibrotic Phenotype Evokes Er-Stress Dependent Pathways During Ecm Remodeling with Covid-19 in Situ

2023-05-18

Abstract excerpt

We recently described a subgroup of autopsied COVID-19 subjects (~40%), termed ‘profibrotic phenotype,’ who exhibited clusters of myofibroblasts (Mfbs), which were positive for the collagen-specific chaperone heat shock protein 47 (HSP47+) in situ. Recruitment of CD163+ macrophages (Mφs) and collagen α1(l)(COLα1) were also identified within HSP47+ “hot spots” relative to controls and other COVID subjects. We now c...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 737e875b-26e5-5b96-aa32-054850404b02
DOI: 10.2139/ssrn.4443002

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cardiac Profibrotic Phenotype Evokes Er-Stress Dependent Pathways During Ecm Remodeling with Covid-19 in SituDOI 10.2139/ssrn.4443002Read

Collagen-Specific HSP47+ Myofibroblasts and CD163+ Macrophages Identify Profibrotic Phenotypes in Deceased Hearts With SARS-CoV-2 Infections.Semantic proximity Read

Idiopathic Inflammatory Myopathies in the Post-COVID-19 Era: A Spotlight on Cardiac ImpairmentSemantic proximity Read

Investigating the Profile of Patients with Idiopathic Inflammatory Myopathies in the Post-COVID-19 Period: Emphasizing Myocardial InjurySemantic proximity Read

Endoplasmic reticulum stress in the pathogenesis of fibrotic diseaseSemantic proximity Read

Cardiovascular disease risk factors induce mesenchymal features and senescence in cardiac endothelial cellsSemantic proximity Read

SARS-CoV-2 infection of human iPSC-derived cardiac cells predicts novel cytopathic features in hearts of COVID-19 patientsSemantic proximity Read

Molecular Pathophysiology of Cardiac Injury and Cardiac Microthrombi in Fatal COVID-19: Insights from Clinico-histopathologic and Single Nuclei RNA Sequencing AnalysesSemantic proximity Read

Red Flags for Differentiating Desmosomal "Hot-Phase" Cardiomyopathy From Acute Myocarditis.Semantic proximity Read

Transcriptomic profiling of cardiac tissues from SARS-CoV-2 patients identifies DNA damageSemantic proximity Read

Multimorbidity increases susceptibility to myocardial injury via dysregulated cardiac macrophage activation and the development of a cardiomyopathy phenotypeSemantic proximity Read

Human Cardiac Organoids to Model COVID-19 Cytokine Storm Induced Cardiac InjuriesSemantic proximity Read

Early Transcriptomic Signatures of Reductive Stress Cardiomyopathy Reveal Insufficient HIF-1α SignalingSemantic proximity Read