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Multimorbidity increases susceptibility to myocardial injury via dysregulated cardiac macrophage activation and the development of a cardiomyopathy phenotype

2024-04-09

Abstract excerpt

<h4>Background</h4> This study investigated mechanisms underlying the association between multimorbidity (MM) and increased susceptibility to myocardial injury and organ failure following cardiac surgery. <h4>Methods</h4> K-means clustering was performed using data from five cardiac surgery cohorts with high prevalence of MM. The resulting Clusters were explored using single nuclei RNA sequencing (snRNAseq) of a...

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Literature Corpus work
2d42f63a-3448-5a82-94ce-4c7995369f35
DOI
10.1101/2024.04.05.24305379
Open publication

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Multimorbidity increases susceptibility to myocardial injury via dysregulated cardiac macrophage activation and the development of a cardiomyopathy phenotypeDOI 10.1101/2024.04.05.24305379
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