Collagen-Specific HSP47+ Myofibroblasts and CD163+ Macrophages Identify Profibrotic Phenotypes in Deceased Hearts With SARS-CoV-2 Infections.

doi:10.1161/JAHA.122.027990

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Collagen-Specific HSP47+ Myofibroblasts and CD163+ Macrophages Identify Profibrotic Phenotypes in Deceased Hearts With SARS-CoV-2 Infections.

Journal of the American Heart Association - 21 Feb 2023

Puzyrenko Andrii, Jacobs Elizabeth R, Padilla Nathan, Devine Adam, Aljadah Michael, Gantner Benjamin N, Pan Amy Y, Lai Shuping, Dai Qiang, Rubenstein Jason C, North Paula E, Simpson Pippa M, Willoughby Rodney E, O'Meara Caitlin C, Flinn Michael A, Lough John W, Ibrahim El-Sayed H, Zheng Ze, Sun Yunguang, Felix Juan, Hunt Bryan C, Ross Gracious, Rui Hallgeir, Benjamin Ivor J

Abstract excerpt

Background Cardiac fibrosis complicates SARS-CoV-2 infections and has been linked to arrhythmic complications in survivors. Accordingly, we sought evidence of increased HSP47 (heat shock protein 47), a stress-inducible chaperone protein that regulates biosynthesis and secretion of procollagen in heart tissue, with the goal of elucidating molecular mechanisms underlying cardiac fibrosis in subjects with this viral...

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PMID: 36789856
DOI: 10.1161/JAHA.122.027990
PMCID: PMC10111490

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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