Article

Analysis and modeling of cancer drug responses using cell cycle phase-specific rate effects

2020-07-25

Abstract excerpt

<h4>ABSTRACT</h4> Identifying effective therapeutic strategies that can prevent tumor cell proliferation is a major challenge to improving outcomes for patients with breast cancer. Here we sought to deepen our understanding of how clinically relevant anti-cancer agents modulate cell cycle progression. We genetically engineered breast cancer cell lines to express a cell cycle reporter and then tracked drug-induced...

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Literature Corpus work: 737d8f8a-4c23-5502-982c-1fdc9a1a1423
DOI: 10.1101/2020.07.24.219907

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