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Article

A mathematical model of subpopulation kinetics for the deconvolution of leukaemia heterogeneity

3 Jun 2015

Abstract excerpt

Acute myeloid leukaemia is characterized by marked inter- and intra-patient heterogeneity, the identification of which is critical for the design of personalized treatments. Heterogeneity of leukaemic cells is determined by mutations which ultimately affect the cell cycle. We have developed and validated a biologically relevant, mathematical model of the cell cycle based on unique cell-cycle signatures, defined...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 26040591
DOI: 10.1098/rsif.2015.0276

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