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Article

Single-Cell Dynamics Determines Response to CDK4/6 Inhibition in Triple-Negative Breast Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Sept 2017

Asghar Uzma S, Barr Alexis R, Cutts Ros, Beaney Matthew, Babina Irina, Sampath Deepak, Giltnane Jennifer, Lacap Jennifer Arca, Crocker Lisa, Young Amy, Pearson Alex, Herrera-Abreu Maria Teresa, Bakal Chris, Turner Nicholas C

Abstract excerpt

Purpose: Triple-negative breast cancer (TNBC) is a heterogeneous subgroup of breast cancer that is associated with a poor prognosis. We evaluated the activity of CDK4/6 inhibitors across the TNBC subtypes and investigated mechanisms of sensitivity.Experimental Design: A panel of cell lines representative of TNBC was tested for in vitro and in vivo sensitivity to CDK4/6 inhibition. A fluorescent CDK2 activity...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28606920
DOI: 10.1158/1078-0432.CCR-17-0369
PMCID: PMC6175044

Genes

CDK4
CDK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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