Article

Arginase 1 is a key driver of immune suppression in pancreatic cancer

2022-06-24

Abstract excerpt

An extensive fibroinflammatory stroma rich in macrophages is a hallmark of pancreatic cancer. In this disease, it is well appreciated that macrophages are immunosuppressive and contribute to the poor response to immunotherapy; however, the mechanisms of immune suppression are complex and not fully understood. Immunosuppressive macrophages are classically defined by expression of the enzyme Arginase 1 (Arg1), which...

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Literature Corpus work: 73421b00-a026-5e29-9f66-31a2f380b7b5
DOI: 10.1101/2022.06.21.497084

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