Article

Feed-forward stimulation of CAMK2 by the oncogenic pseudokinase PEAK1 generates a therapeutically ‘actionable’ signalling axis in triple negative breast cancer

2024-02-15

Abstract excerpt

<h4>Summary</h4> The PEAK family of pseudokinases, comprising PEAK1-3, are signalling scaffolds that play oncogenic roles in several poor prognosis human cancers, including triple negative breast cancer (TNBC). However, therapeutic targeting of pseudokinases is challenging due to their lack of catalytic activity. To address this, we screened for PEAK1 effectors by affinity purification and mass spectrometry, iden...

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Literature Corpus work: bdb8326f-c9ff-5eca-ad00-d2a5f882276c
DOI: 10.1101/2024.02.14.580406

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Feed-forward stimulation of CAMK2 by the oncogenic pseudokinase PEAK1 generates a therapeutically ‘actionable’ signalling axis in triple negative breast cancerDOI 10.1101/2024.02.14.580406Read

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