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The PIK3CA gene and its pivotal role in tumor tropism of triple-negative breast cancer

5 Oct 2024

Abstract excerpt

The PIK3CA gene is a linchpin in the intricate molecular network governing triple-negative breast cancer (TNBC) tumor tropism, serving as a focal point for understanding this aggressive disease. Anchored within the PI3K/AKT/mTOR signaling axis, PIK3CA mutations exert substantial influence, driving cellular processes that highlight the unique biology of TNBC. This review meticulously highlights the association...

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PMID: 39369580
DOI: 10.1016/j.tranon.2024.102140

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