Article

IRAK2 contributes to triple-negative breast cancer growth via NF-κB, ERK and stress-related signaling pathways

2022-07-06

Abstract excerpt

<h4>Purpose: </h4> We previously screened kinases whose depletion elicited a differentiation response of the triple-negative breast cancer (TNBC) cell line MDA-MB-468. In particular, we demonstrated that the downregulation of the kinases ERN1 and ALPK1 affected cellular proliferation, self-renewal and tumor-forming capacity. Interleukin-1 receptor-associated kinase 2 (IRAK2) was identified in the screening and IRA...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ad1a6ccc-41a8-5baa-9bdd-20860eacdad1
DOI: 10.21203/rs.3.rs-1802684/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

IRAK2 contributes to triple-negative breast cancer growth via NF-κB, ERK and stress-related signaling pathwaysDOI 10.21203/rs.3.rs-1802684/v1Read

Activated kinase screening identifies the IKBKE oncogene as a positive regulator of autophagySemantic proximity Read

Reverse molecular pharmacology identifies the non-canonical axis of IRAK as a chemoresistance factor in neuroblastomaSemantic proximity Read

Highly expressed SERCA2 triggers tumor cell autophagy and is a druggable vulnerability in triple-negative breast cancerSemantic proximity Read

Proteomic and Transcriptomic Profiling Identifies Mediators of Anchorage-Independent Growth and Roles of Inhibitor of Differentiation Proteins in Invasive Lobular Breast CancerSemantic proximity Read

ERN1 and ALPK1 inhibit differentiation of bi-potential tumor-initiating cells in human breast cancer.Semantic proximity Read

Addiction to the IGF2-ID1-IGF2 circuit for maintenance of the breast cancer stem-like cellsSemantic proximity Read

IRAK1 is a critical mediator of low molecular weight hyaluronic acid-induced stemness in high-grade serous ovarian cancerSemantic proximity Read

Isolation and characterization of a new naturally immortalized human breast carcinoma cell line, KAIMRC1Semantic proximity Read

Proteomic and transcriptomic profiling identifies mediators of anchorage-independent growth and roles of inhibitor of differentiation proteins in invasive lobular carcinomaSemantic proximity Read

NF-κB non-cell-autonomously regulates cancer stem cell populations in the basal-like breast cancer subtypeSemantic proximity Read

PERK-Olating Through Cancer: A Brew of Cellular DecisionsSemantic proximity Read

ErbB receptor tyrosine kinase/NF-κB signaling controls mammosphere formation in human breast cancerSemantic proximity Read