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Article

Nucleotide- and Protein-Dependent Functions of Actg1.

Molecular biology of the cell - 1 Aug 2022

Sundby Lauren J, Southern William M, Hawbaker Katelin M, Trujillo Jesús M, Perrin Benjamin J, Ervasti James M

Abstract excerpt

Cytoplasmic β- and γ-actin proteins are 99% identical but support unique organismal functions. The cytoplasmic actin nucleotide sequences Actb and Actg1, respectively, are more divergent but still 89% similar. Actb-/- mice are embryonic lethal and Actb-/- cells fail to proliferate, but editing the Actb gene to express γ-actin (Actbc-g) resulted in none of the overt phenotypes of the knockout revealing...

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Identifiers

PMID: 35594181
DOI: 10.1091/mbc.E22-02-0054
PMCID: PMC9582642

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