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Article

Cell-Intrinsic Adaptation Arising from Chronic Ablation of a Key Rho GTPase Regulator.

Developmental cell - 10 Oct 2016

Cerikan Berati, Shaheen Ranad, Colo Georgina P, Gläßer Christine, Hata Shoji, Knobeloch Klaus-Peter, Alkuraya Fowzan S, Fässler Reinhard, Schiebel Elmar

Abstract excerpt

Genome-editing technologies allow systematic inactivation of human genes. Whether knockout phenotypes always reflect gene functions as determined by acute RNAi is an important question. Here we show how the acute knockdown of the Adams-Oliver syndrome (AOS) gene DOCK6, coding for a RAC1/CDC42 guanine nucleotide exchange factor, results in strikingly different phenotypes to those generated by genomic DOCK6...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Limb Deformities, Congenital

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Source

Identifiers

PMID: 27693507
DOI: 10.1016/j.devcel.2016.08.020

Genes

DOCK6
CDC42
ISG15
RAC1
IQGAP1
SRF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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