Transcription factor NF-E2-related factor 1 impairs glucose metabolism in mice.

doi:10.1111/gtc.12165

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Article

Transcription factor NF-E2-related factor 1 impairs glucose metabolism in mice.

Genes to cells : devoted to molecular & cellular mechanisms - 1 Aug 2014

Hirotsu Yosuke, Higashi Chika, Fukutomi Toshiaki, Katsuoka Fumiki, Tsujita Tadayuki, Yagishita Yoko, Matsuyama Yuka, Motohashi Hozumi, Uruno Akira, Yamamoto Masayuki

Abstract excerpt

Nrf1 (NF-E2-related factor 1) is a basic region leucine zipper-type transcription factor belonging to the CNC (cap-'n'-collar) family. Major pathophysiological contribution of Nrf1 remains unclear. As single nucleotide polymorphism rs3764400 in 5'-flanking region of NRF1 gene appears to associate with obesity, in this study, we focused on the Nrf1 function on metabolism. We found that the risk C allele of...

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PMID: 25041126
DOI: 10.1111/gtc.12165

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NRF1

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