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Inhibition of hexokinase 2 undermines cartilage health and accelerates osteoarthritis

2026-05-29

Abstract excerpt

<h4>Objective</h4> Enhanced glycolysis is a metabolic hallmark of chondrocytes in osteoarthritis (OA); however, the roles of the glycolytic rate-limiting enzyme hexokinase 2 (HK2) in cartilage remain poorly understood. <h4>Methods</h4> Pharmacological approach (3-bromopyruvate (3-BrPA) treatment) and mice model involving HK2 knockout in Col2a1-expressing chondrocytes are utilized to access the impact of HK2 bloc...

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Literature Corpus work
72afaa92-a557-565d-8655-0271f8a9220c
DOI
10.64898/2026.05.26.728030
Open publication

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