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Decoding Glycolysis Mechanisms and Cellular Heterogeneity in Intervertebral Disc Degeneration via scRNA-seq and Bulk RNA-seq

2026-08-13

Abstract excerpt

<title>Abstract</title> <p>Intervertebral disc degeneration (IDD) is a major contributor to chronic low back pain; however, the metabolic alterations and cellular mechanisms driving its progression remain incompletely understood. Increasing evidence indicates that glycolytic reprogramming is closely associated with inflammatory responses, oxidative stress, and extracellular matrix (ECM) degradation during degener...

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Literature Corpus work
5ae8e75a-c98d-52b0-ac06-01e6bbfe3305
DOI
10.21203/rs.3.rs-10401482/v1
Open publication

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