Article
Down-regulated HS6ST2 in osteoarthritis and Kashin-Beck disease inhibits cell viability and influences expression of the genes relevant to aggrecan metabolism of human chondrocytes.
Rheumatology (Oxford, England) - 1 Dec 2011
Wang Wei, Zhong Bo, Sun Jian, Cao Junling, Tian Juan, Zhong Nannan, Zhao Wenxiang, Tian Lifang, Xu Peng, Guo Dawei, Ju Xichi, Ma Wei, Li Meng, Hou Weikun, Lu Shemin
Abstract excerpt
OBJECTIVE: Primary OA and Kashin-Beck disease (KBD) show similar pathological changes in articular cartilage. The objective was to screen differentially expressed genes between OA and normal cartilage, confirm the candidate gene expression among OA, KBD and normal cartilage, and then clarify its role in vitro. METHODS: Differentially expressed genes in OA cartilage were screened by suppression subtractive...
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