Article

<i>Lmna</i> deficiency promotes EPHX2 nuclear translocation to ameliorate cardiac dysfunction in mice

2026-02-10

Abstract excerpt

<h4>Background</h4> Cardiovascular diseases are often associated with altered protein subcellular localization. As a major cause of inherited cardiomyopathy, LMNA deficiency could trigger nuclear envelope rupture and broadly impair the localization of nuclear and cytoplasmic proteins. Systemic approaches to identify, dissect and manipulate the localization of endogenous proteins are important for mechanistic and...

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Literature Corpus work: 41455fb8-3cc2-5e15-93f4-0ddf2979b8c9
DOI: 10.64898/2026.02.09.704693

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