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The Terminator mouse is a diphtheria toxin-receptor knock-in mouse strain for rapid and efficient enrichment of desired cell lineages.

Kidney international - 1 Nov 2013

Guo Jian-Kan, Shi Hongmei, Koraishy Farrukh, Marlier Arnaud, Ding Zhaowei, Shan Alan, Cantley Lloyd G

Abstract excerpt

Biomedical research often requires primary cultures of specific cell types, which are challenging to obtain at high purity in a reproducible manner. Here we engineered the murine Rosa26 locus by introducing the diphtheria toxin receptor flanked by loxP sites. The resultant strain was nicknamed the Terminator mouse. This approach results in diphtheria toxin-receptor expression in all non-Cre expressing cell types,...

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Identifiers

PMID: 23739236
DOI: 10.1038/ki.2013.202
PMCID: PMC3775868

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