Article

MG132 induces progerin clearance and improves disease phenotypes in fibroblasts of patients affected with Hutchinson-Gilford Progeria-like syndromes

2021-04-14

Abstract excerpt

<h4>ABSTRACT</h4> Progeroid Syndromes (PS), including Hutchinson-Gilford Progeria Syndrome (HGPS, OMIM #176670), are premature and accelerated aging that clinically resemble some aspects of advancing physiological aging. Most classical HGPS patients carry a de novo point mutation within exon 11 of the LMNA gene encoding A-type Lamins. This mutation activates a cryptic splice site leading to the deletion of 50 a...

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Literature Corpus work: 728baaea-fadf-532c-bb5b-005bd238fdac
DOI: 10.1101/2021.04.14.439612

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