Reduced hydroxymethylation characterizes medulloblastoma while TET and IDH genes are differentially expressed within molecular subgroups.

doi:10.1007/s11060-018-2845-1

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Article

Reduced hydroxymethylation characterizes medulloblastoma while TET and IDH genes are differentially expressed within molecular subgroups.

Journal of neuro-oncology - 1 Aug 2018

Bezerra Salomão Karina, Cruzeiro Gustavo Alencastro Veiga, Bonfim-Silva Ricardo, Geron Lenisa, Ramalho Fernando, Pinto Saggioro Fabiano, Serafini Luciano Neder, Antunes Moreno Daniel, de Paula Queiroz Rosane Gomes, Dos Santos Aguiar Simone, Cardinalli Izilda, Yunes José Andres, Brandalise Silvia Regina, Brassesco Maria Sol, Scrideli Carlos Alberto, Gonzaga Tone Luiz

Abstract excerpt

INTRODUCTION: Medulloblastoma (MB) is an embryonal tumour that originates from genetic deregulation of cerebellar developmental pathways and is classified into 4 molecular subgroups: SHH, WNT, group 3, and group 4. Hydroxymethylation levels progressively increases during cerebellum development suggesting a possibility of deregulation in MB pathogenesis. The aim of this study was to investigate global...

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Identifiers

PMID: 29582271
DOI: 10.1007/s11060-018-2845-1

Genes

IDH1
SHH
TET3
IDH2
TET1

Provenance

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